In this article we will explore the intersection of sexual health, relationships, premature ejaculation (PE), and Zoloft (Sertraline). Patients often ask if Zoloft be used to treat PE, and we explore this question in-depth in the article below. If you are looking for a straightforward answer about Zoloft to treat PE, please scroll down to the bottom of this article. What is Zoloft? Zoloft is a medication that is part of the selective serotonin reuptake inhibitor class of medications, also referred to as SSRI’s. Other commonly known SSRI’s include Lexapro, Prozac, Celexa and Paxil. This class of medication is considered a